How can the effect of medical treatment be enhanced and extended to provide comprehensive support and nourishment to the joints?
Orthopedic disorders in horses are the most common cause of lameness, leading to horses being excluded from work (Bromiley M., 2009). Treatment and rehabilitation are arduous and lengthy processes, so the prevention of musculoskeletal disorders is becoming increasingly important.
HorseLinePRO ChondroVET + HA – Use in Nutrition
Numerous active ingredients have been studied for their suitability for dietary chondroprotective prevention, and their efficacy has been confirmed in numerous clinical studies.
Osteoarthritis often begins with overloading or necrosis of chondrocytes. Cartilage loss occurs due to an imbalance between the synthesis and breakdown of the articular cartilage matrix (hyaluronic acid and proteoglycans) (Barr A. R. S., 1991). Therapies aim to reduce the release of cytokines from synovial cells and cartilage-degrading enzymes while also neutralizing free radicals, stimulating cartilage synthesis, and improving the lubricating function of joint fluid (Pinals R.S., 1992).
Cycle of Osteoarthritis Development
Osteoarthritis can be triggered by stress, age, injuries, wear, or damage. It leads to a vicious cycle of inflammation and cartilage breakdown (Banagry, 1994).
HorseLinePRO ChondroVET + HA is a professional preparation with very high efficacy, based on active ingredients from the SYSADOA group (Symptomatic Slow Acting Drugs for Osteoarthritis).
Hyaluronic Acid (1000 mg/24h/550 kg BW)
Hyaluronic acid is synthesized by chondrocytes and is a natural component of connective tissue matrix and joint fluid. It ensures the viscosity and lubricating capacity of the joints. Additionally, it acts as an elastic buffer against pressure and stress (Prehm P., 1986).
Supplementation of hyaluronic acid improves the consistency of joint fluid, enhances its lubricating and shock-absorbing properties, and protects joint surfaces from damage. It has anti-inflammatory effects and regulates cellular functions (Balogh L. et al., 2008).
Glucosamine Hydrochloride and Chondroitin Sulfate
Both substances are essential components of joint fluid and promote cartilage tissue regeneration. They work synergistically, enhancing their efficacy. Studies show that their supplementation improves joint mobility and reduces degenerative changes (Hanson R.R. et al., 1997).
Glucosamine Hydrochloride (11000 mg/24h/550 kg BW)
Glucosamine stimulates the synthesis of proteoglycans and promotes cartilage tissue regeneration. It reduces inflammation, alleviates pain, and increases the elasticity and resilience of joints. Clinical studies show that glucosamine hydrochloride protects the surface of joints and improves joint function (Uldry M. et al., 2002).
Chondroitin Sulfate (4000 mg/24h/550 kg BW)
Chondroitin sulfate is a major component of joint fluid. It stabilizes joint gaps, reduces inflammation, and improves shock absorption in joints. Studies demonstrate that chondroitin sulfate supplementation promotes cartilage health and enhances mobility (Frisbie D.D. et al., 1999).
MSM (5000 mg/24h/550 kg BW)
Methylsulfonylmethane (MSM) is an organic sulfur compound that supports cartilage tissue regeneration, reduces oxidative stress, and has anti-inflammatory effects. It enhances nutrient transport to cells and supports collagen formation (Marañón G. et al., 2008).
Vitamin C (5000 mg/24h/550 kg BW)
Vitamin C supports the synthesis of collagen, elastin, and hyaluronic acid. It has anti-inflammatory and antioxidant properties, which help relieve pain and improve mobility (Deaton C.M. et al., 2002).
Conclusion
HorseLinePRO ChondroVET + HA provides comprehensive protection and support for the musculoskeletal system of horses. It is suitable for prevention and as a supplement during rehabilitation. Its efficacy is clinically proven, and the active ingredients are optimally tailored to the needs of horses.
References
- Bromiley M., 2009: Injuries in Horses, Treatment, and Rehabilitation.
- Hanson R.R., Smalley L.R., Huff G.K., White S., Hammad T.A., 1997: Oral Treatment with a Glucosamine-Chondroitin Sulfate Compound.
- Balogh L., Polyak A., Mathe D. et al., 2008: Hyaluronic Acid and Its Importance for Joint Health.
- Marañón G., Muñoz-Escassi B., Manley W. et al., 2008: Effects of MSM on Sport Horses.
- Deaton C.M., Marlin D.J., Roberts C.A. et al., 2002: Antioxidant Effects of Vitamin C.
- Banagry T.B., 1994: Therapy of Equine Joint Disorders.
- Barr A.R.S., 1991: A Study of Carpal Injuries in the Horse.
- Prehm P., 1986: Mechanism, Localization, and Inhibition of Hyaluronate.
- Pinals R.S., 1992: Mechanisms in Osteoarthritis Therapy.
- Frisbie D.D., Ray C.S., Ionescu M., Poole A.R., Chapman P.L., McIlwraith C.W., 1999: Proteoglycans in Equine Joint Health.
- Uldry M., Ibberson M., Hosokawa M. et al., 2002: GLUT2 as a High Affinity Glucosamine Transporter.
- Liu X., Eyles J., McLachlan A.J., Mobasheri A., 2018: Supplements in Osteoarthritis Management.
- Elves M.V., 1991: New Drugs for Osteoarthritis.
- Zubrzycka-Sienkiewicz A., 2009: Osteoarthritis in Veterinary Science.
- Stanislawska-Biernat E., Filipowicz-Sosnowska A., 2004: Treatment Strategies in Osteoarthritis.
- Sutton L., Rapport L., Lockwood B., 2002: Glucosamine in Joint Health.
- Barmaki S., Bohlooli S., Khoshkhahesh F., Nakhostin-Roohi B., 2012: Effects of MSM on Oxidative Stress.
- Snow D.H., Gash S.P., Cornelius J., 1987: Vitamin C in Equine Joint Recovery.
